Methyl chloroformate → Methyl 6-chloro-2-fluoronicotinate

HRID 835815Notes

Reaction equation

HRID 835815 reaction equation
[CH2:9]([Li:10])[CH2:11][CH2:12][CH3:13].[Cl:14][C:15](=[O:16])[O:17][CH3:18].[Cl:1][c:2]1[n:3][c:4]([F:8])[cH:5][cH:6][cH:7]1.[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1>>[Cl:1][c:2]1[n:3][c:4]([F:8])[c:5]([C:15](=[O:16])[O:17][CH3:18])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6586Methyl chloroformateHCID 8028TetrahydrofuranHCID 6394372-Chloro-6-fluoropyridineHCID 178418339Butyllithium

Product 1

HCID 59526352Methyl 6-chloro-2-fluoronicotinate

Sources & evidence

ORD record
ord-996139f2cc014522af3b2c17631d584a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…