Carbon Tetrachloride → Diethyl[(6-bromo-2-cyanoquinolin-7-yl)(difluoro)methyl]phosphonate

HRID 835817Notes

Reaction equation

HRID 835817 reaction equation
[C:45]([Cl:46])([Cl:47])([Cl:48])[Cl:49].[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[C:9]([F:10])([F:11])[c:12]1[c:13]([Br:25])[cH:14][c:15]2[cH:16][cH:17][c:18]([CH:22]=[N:23][OH:24])[n:19][c:20]2[cH:21]1.[CH3:50][C:51]#[N:52].[c:26]1([P:27]([c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[cH:40][cH:41][cH:42][cH:43][cH:44]1>>[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[C:9]([F:10])([F:11])[c:12]1[c:13]([Br:25])[cH:14][c:15]2[cH:16][cH:17][c:18]([C:22]#[N:23])[n:19][c:20]2[cH:21]1

Participants

5

Reactant 4

HCID 5943Carbon TetrachlorideHCID 6342AcetonitrileHCID 11776TriphenylphosphineHCID 145737911N-[[6-bromo-7-[diethoxyphosphoryl(difluoro)methyl]quinolin-2-yl]methylidene]hydroxylamine

Product 1

HCID 86638326Diethyl[(6-bromo-2-cyanoquinolin-7-yl)(difluoro)methyl]phosphonate

Sources & evidence

ORD record
ord-450044b693b8469b9d934a285f72a7f0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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