反应详情

A solution of the product of Step B (2.6 g) and 2-amino-4-picoline (0.96 g) in ethanol (10 mL) was heated at 73° C. for 2 hours. The reaction mixture was cooled to ambient temperature and the solvent evaporated in vacuo. The residue was dissolved in dichloromethane (75 mL), washed with saturated sodium bicarbonate solution (2×75 mL), brine (75 mL), dried over magnesium sulfate, filtered and evaporated. The residue was purified via silica gel chromatography (ethyl acetate/hexane) to give the title compound (1.3 g).

1. customthe solvent evaporated in vacuo
2. dissolutionThe residue was dissolved in dichloromethane (75 mL)
3. washwashed with saturated sodium bicarbonate solution (2×75 mL), brine (75 mL)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated
7. customThe residue was purified via silica gel chromatography (ethyl acetate/hexane)