Allyl bromide → Diethyl 4-(allylethylamino)benzylacetamidomalonate

HRID 836281Notes

Reaction equation

HRID 836281 reaction equation
[CH2:1]([CH3:2])[NH:3][c:4]1[cH:5][cH:6][c:7]([CH2:8][CH2:9][C:10](=[O:11])[NH:12][CH:13]([C:14](=[O:15])[O:16][CH2:17][CH3:18])[C:19](=[O:20])[O:21][CH2:22][CH3:23])[cH:24][cH:25]1.[CH2:26]([CH:27]=[CH2:28])[Br:29].[N:30]12[CH2:31][CH2:32][CH2:33][C:34]1=[N:35][CH2:36][CH2:37][CH2:38]2.[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1>>[CH2:1]([CH2:2][CH2:28][CH:27]=[CH2:26])[NH:3][c:4]1[cH:5][cH:6][c:7]([CH2:8][CH2:9][C:10](=[O:11])[NH:12][CH:13]([C:14](=[O:15])[O:16][CH2:17][CH3:18])[C:19](=[O:20])[O:21][CH2:22][CH3:23])[cH:24][cH:25]1

Participants

5

Reactant 4

HCID 7841Allyl bromideHCID 8028TetrahydrofuranHCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 54294942Diethyl 4-ethylaminobenzylacetamidomalonate

Product 1

HCID 69892586Diethyl 4-(allylethylamino)benzylacetamidomalonate

Sources & evidence

ORD record
ord-b8583835542d4eed9109c4f43fe34a22
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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