Hydrochloric Acid → 5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluorobenzonitrile

HRID 836370Notes

Reaction equation

HRID 836370 reaction equation
[Cl:3][c:4]1[cH:5][c:6]2[c:7]([n:8][cH:9][n:10][c:11]2[NH:12][CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[s:19]1.[ClH:1].[ClH:2].[F:20][c:21]1[c:22]([C:23]#[N:24])[cH:25][c:26]([CH:29]=[O:30])[cH:27][cH:28]1>>[Cl:3][c:4]1[cH:5][c:6]2[c:7]([n:8][cH:9][n:10][c:11]2[NH:12][CH:13]2[CH2:14][CH2:15][N:16]([CH2:29][c:26]3[cH:25][c:22]([C:23]#[N:24])[c:21]([F:20])[cH:28][cH:27]3)[CH2:17][CH2:18]2)[s:19]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 27695822-Fluoro-5-formylbenzonitrileHCID 579331476-chloro-N-(piperidin-4-yl)thieno[2,3-d]pyrimidin-4-amine

Product 1

HCID 115022435-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluorobenzonitrile

Sources & evidence

ORD record
ord-857d8ca4af98431eafbe696aa7faecb4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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