反应详情

A solution of the product of Step A (2.3 g) in ether (10 mL) was treated with bromine (0.51 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (40 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (40 mL). The combined organic layers were washed with a fresh portion of water (50 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (3.1 g).

1. customthe organic layer was separated
2. washThe aqueous layer was washed with a fresh portion of ether (40 mL)
3. washThe combined organic layers were washed with a fresh portion of water (50 mL)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated