2-Morpholinoethylamine → 6-[2-(2-Morpholin-4-ylethylamino)pyrimidin-4-yl]-2-(2-trimethylsilanyl-ethoxymethyl)-4-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2H-pyridazin-3-one

HRID 836455Notes

Reaction equation

[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[cH:9][c:10](-[c:23]3[n:24][c:25]4[c:26]([n:27]3[CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37][cH:38][cH:39]4)[c:11](=[O:22])[n:12]([CH2:14][O:15][CH2:16][CH2:17][Si:18]([CH3:19])([CH3:20])[CH3:21])[n:13]2)[n:7]1.[NH2:40][CH2:41][CH2:42][N:43]1[CH2:44][CH2:45][O:46][CH2:47][CH2:48]1>>[c:2]1([NH:40][CH2:41][CH2:42][N:43]2[CH2:44][CH2:45][O:46][CH2:47][CH2:48]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[cH:9][c:10](-[c:23]3[n:24][c:25]4[c:26]([n:27]3[CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37][cH:38][cH:39]4)[c:11](=[O:22])[n:12]([CH2:14][O:15][CH2:16][CH2:17][Si:18]([CH3:19])([CH3:20])[CH3:21])[n:13]2)[n:7]1

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 866116106-(2-chloropyrimidin-4-yl)-2-(2-trimethylsilanylethoxymethyl)-4-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2H-pyridazin-3-one

Product 1

HCID 686811726-[2-(2-Morpholin-4-ylethylamino)pyrimidin-4-yl]-2-(2-trimethylsilanyl-ethoxymethyl)-4-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2H-pyridazin-3-one

Sources & evidence

ORD record: ord-5e2c80dfd6c24a36ba47823d5d861187
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…