Dichloromethane → 1-(4-Methoxybenzyl)piperidin-4-amine

HRID 836513Notes

Reaction equation

HRID 836513 reaction equation
[CH2:31]([Cl:32])[Cl:33].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([NH:16][C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15]2)[cH:7][cH:8]1.[OH:24][C:25]([C:26]([F:27])([F:28])[F:29])=[O:30]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([NH2:16])[CH2:14][CH2:15]2)[cH:7][cH:8]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 13370621tert-Butyl 1-(4-methoxybenzyl)piperidin-4-ylcarbamate

Product 1

HCID 126418411-(4-Methoxybenzyl)piperidin-4-amine

Sources & evidence

ORD record
ord-89ba3cf9112e4ff1afb7fd0540614103
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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