Dichloromethane → N-(2-fluorophenyl)-4-[(2'-oxo-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-1'(2'H)-yl)methyl]benzamide

HRID 836516Notes

Reaction equation

HRID 836516 reaction equation
[CH3:9][CH2:10][N:11]([CH2:12][CH3:13])[CH2:14][CH3:15].[Cl:48][CH2:49][Cl:50].[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[F:8].[O:16]=[C:17]1[N:18]([CH2:38][c:39]2[cH:40][cH:41][c:42]([C:43](=[O:44])[Cl:45])[cH:46][cH:47]2)[c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[C:25]12[CH2:26][O:27][c:28]1[c:29]2[cH:30][c:31]2[c:36]([cH:37]1)[O:35][CH2:34][CH2:33][O:32]2>>[NH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[F:8])[C:43]([c:42]1[cH:41][cH:40][c:39]([CH2:38][N:18]2[C:17](=[O:16])[C:25]3([c:24]4[c:19]2[cH:20][cH:21][cH:22][cH:23]4)[CH2:26][O:27][c:28]2[c:29]3[cH:30][c:31]3[c:36]([cH:37]2)[O:35][CH2:34][CH2:33][O:32]3)[cH:47][cH:46]1)=[O:44]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 95842-FluoroanilineHCID 866421984-((2'-oxo-3,7-dihydro-2H-spiro[benzofuro[5,6-b][1,4]dioxine-8,3'-indoline]-1'-yl)methyl)benzoyl chloride

Product 1

HCID 59352556N-(2-fluorophenyl)-4-[(2'-oxo-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-1'(2'H)-yl)methyl]benzamide

Sources & evidence

ORD record
ord-d643b4539aa94756905834ae920dcbbb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…