Potassium Cation → Ethyl 3-[4-({4'-[3-(diethoxyphosphoryl)propoxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2-fluorophenyl]propanoate

HRID 836600Notes

Reaction equation

HRID 836600 reaction equation
[Br:34][CH2:35][CH2:36][CH2:37][P:38]([O:39][CH2:40][CH3:41])([O:42][CH2:43][CH3:44])=[O:45].[CH3:48][N:49]([CH3:50])[CH:51]=[O:52].[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([O:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([OH:23])[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1.[H-:32].[I-:47].[K+:46].[Na+:33]>>[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([O:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([O:23][CH2:35][CH2:36][CH2:37][P:38]([O:39][CH2:40][CH3:41])([O:42][CH2:43][CH3:44])=[O:45])[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1

Participants

8

Reactant 7

HCID 813Potassium CationHCID 923Sodium ionHCID 6228DimethylformamideHCID 30165Iodide IonHCID 166653HydrideHCID 283500Diethyl (3-bromopropyl)phosphonateHCID 58903128Ethyl 3-{2-fluoro-4-[(4'-hydroxy-2',6'-dimethylbiphenyl-3-yl)methoxy]phenyl}propanoate

Product 1

HCID 58903140Ethyl 3-[4-({4'-[3-(diethoxyphosphoryl)propoxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2-fluorophenyl]propanoate

Sources & evidence

ORD record
ord-9aab000eaf7b435dbc9c544ee4779003
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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