Isopropanol → 2-[5-Chloro-2-(1-ethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3,N-dimethyl-benzamide

HRID 836943Notes

Reaction equation

HRID 836943 reaction equation
[CH:36]([OH:37])([CH3:38])[CH3:39].[Cl:16][c:17]1[n:18][cH:19][c:20]([Cl:35])[c:21]([NH:23][c:24]2[c:25]([C:26](=[O:27])[NH:28][CH3:29])[cH:30][cH:31][cH:32][c:33]2[CH3:34])[n:22]1.[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:14][cH:15]1)[CH2:6][CH2:7][CH2:8][C:9](=[O:13])[N:10]2[CH2:11][CH3:12]>>[NH:1]([c:2]1[cH:3][c:4]2[c:5]([cH:14][cH:15]1)[CH2:6][CH2:7][CH2:8][C:9](=[O:13])[N:10]2[CH2:11][CH3:12])[c:17]1[n:18][cH:19][c:20]([Cl:35])[c:21]([NH:23][c:24]2[c:25]([C:26](=[O:27])[NH:28][CH3:29])[cH:30][cH:31][cH:32][c:33]2[CH3:34])[n:22]1

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 98991662H-1-Benzazepin-2-one, 8-amino-1-ethyl-1,3,4,5-tetrahydro-HCID 866338742-(2,5-dichloropyrimidin-4-ylamino)-N,3-dimethylbenzamide

Product 1

HCID 668299372-[5-Chloro-2-(1-ethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3,N-dimethyl-benzamide

Sources & evidence

ORD record
ord-92984bec14b4439ebe23b9fe64c9f7a9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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