Methanol → 1-(p-Nitrobenzyloxycarbonyl)-4-hydroxypiperidine

HRID 836997Notes

Reaction equation

HRID 836997 reaction equation
[BH4-:21].[CH3:23][OH:24].[N+:1](=[O:2])([O-:3])[c:4]1[cH:5][cH:6][c:7]([CH2:8][O:9][C:10](=[O:11])[N:12]2[CH2:13][CH2:14][C:15](=[O:18])[CH2:16][CH2:17]2)[cH:19][cH:20]1.[Na+:22].[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1.[OH2:30]>>[N+:1](=[O:2])([O-:3])[c:4]1[cH:5][cH:6][c:7]([CH2:8][O:9][C:10](=[O:11])[N:12]2[CH2:13][CH2:14][CH:15]([OH:18])[CH2:16][CH2:17]2)[cH:19][cH:20]1

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 28123BorohydrideHCID 13292708(4-Nitrophenyl)methyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 132927091-(p-Nitrobenzyloxycarbonyl)-4-hydroxypiperidine

Sources & evidence

ORD record
ord-b91c16ee10724e949ab17d477f2cf411
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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