Water → propan-2-yl N-[4-[(4-chloro-3-methoxy-2-pyridinyl)methyl]-7-cyano-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate

HRID 837047Notes

Reaction equation

HRID 837047 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][c:5]2[c:6]3[c:7]([nH:8][c:9]2[cH:10][cH:11]1)[CH2:12][CH:13]([NH:15][C:16]([O:17][CH:18]([CH3:19])[CH3:20])=[O:21])[CH2:14]3.[C:33](=[O:34])([O-:35])[O-:36].[CH3:39][N:40]([CH3:41])[CH:42]=[O:43].[Cl:22][c:23]1[c:24]([O:31][CH3:32])[c:25]([CH2:29][Cl:30])[n:26][cH:27][cH:28]1.[Cs+:37].[Cs+:38].[OH2:44]>>[C:1](#[N:2])[c:3]1[cH:4][c:5]2[c:6]3[c:7]([n:8]([CH2:29][c:25]4[c:24]([O:31][CH3:32])[c:23]([Cl:22])[cH:28][cH:27][n:26]4)[c:9]2[cH:10][cH:11]1)[CH2:12][CH:13]([NH:15][C:16]([O:17][CH:18]([CH3:19])[CH3:20])=[O:21])[CH2:14]3

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 118163554-chloro-2-(chloromethyl)-3-methoxypyridineHCID 66933210propan-2-yl N-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamate

Product 1

HCID 66933263propan-2-yl N-[4-[(4-chloro-3-methoxy-2-pyridinyl)methyl]-7-cyano-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate

Sources & evidence

ORD record
ord-7fc80a3599bd4128b8633ef48a05791e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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