Acetonitrile → 5-Chloro-2-{4-[(6-trifluoromethyl-pyridin-3-ylmethyl)-amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl}-benzonitrile

HRID 837289Notes

Reaction equation

HRID 837289 reaction equation
[CH3:42][C:43]#[N:44].[CH:33]([N:34]([CH2:35][CH3:36])[CH:37]([CH3:38])[CH3:39])([CH3:40])[CH3:41].[Cl:23][c:24]1[cH:25][cH:26][c:27]([F:32])[c:28]([C:29]#[N:30])[cH:31]1.[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([CH2:9][NH:10][c:11]2[c:12]3[c:13]([n:14][cH:15][n:16]2)[CH2:17][CH2:18][NH:19][CH2:20]3)[cH:7][n:8]1)([F:21])[F:22]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([CH2:9][NH:10][c:11]2[c:12]3[c:13]([n:14][cH:15][n:16]2)[CH2:17][CH2:18][N:19]([c:27]2[cH:26][cH:25][c:24]([Cl:23])[cH:31][c:28]2[C:29]#[N:30])[CH2:20]3)[cH:7][n:8]1)([F:21])[F:22]

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 936535-Chloro-2-fluorobenzonitrileHCID 59840682N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

Product 1

HCID 250618735-Chloro-2-{4-[(6-trifluoromethyl-pyridin-3-ylmethyl)-amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl}-benzonitrile

Sources & evidence

ORD record
ord-c84fcbcdfc65403988c5303576e123fd
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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