Acetate → Ethyl 3-(1,1-dimethylethyl)-1-(3-fluorophenyl)-1H-pyrazole-5-carboxylate

HRID 837658Notes

Reaction equation

HRID 837658 reaction equation
[C:11]([CH3:12])([CH3:13])([CH3:14])[c:15]1[n:16][nH:17][c:18]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[cH:19]1.[C:40]([O-:41])(=[O:42])[CH3:43].[C:45]([O-:46])(=[O:47])[CH3:48].[CH3:34][CH2:35][O:36][C:37]([CH3:38])=[O:39].[Cl:31][CH2:32][Cl:33].[Cu+2:44].[F:1][c:2]1[cH:3][c:4]([B:8]([OH:9])[OH:10])[cH:5][cH:6][cH:7]1.[cH:25]1[cH:26][cH:27][n:28][cH:29][cH:30]1>>[F:1][c:2]1[cH:3][c:4](-[n:17]2[n:16][c:15]([C:11]([CH3:12])([CH3:13])[CH3:14])[cH:19][c:18]2[C:20](=[O:21])[O:22][CH2:23][CH3:24])[cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1049PyridineHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 27099Cupric cationHCID 27339863-Fluorophenylboronic acidHCID 2743509Ethyl 3-tert-butyl-1H-pyrazole-5-carboxylate

Product 1

HCID 69042455Ethyl 3-(1,1-dimethylethyl)-1-(3-fluorophenyl)-1H-pyrazole-5-carboxylate

Sources & evidence

ORD record
ord-64c1439a613b4fcb835485d321685cb6
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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