Tetrahydrofuran → methyl 2-(4-(4-(N-(2-(tert-butyldimethylsilyloxy) ethyl)-4,6-dichloropyrimidine-5-carboxamido)-3-fluorophenyl)cyclohexyl)acetate
Reaction equation
[C:12]([CH3:13])([CH3:14])([CH3:15])[Si:16]([O:17][CH2:18][CH2:19][NH:20][c:21]1[c:22]([F:38])[cH:23][c:24]([CH:27]2[CH2:28][CH2:29][CH:30]([CH2:33][C:34](=[O:35])[O:36][CH3:37])[CH2:31][CH2:32]2)[cH:25][cH:26]1)([CH3:39])[CH3:40].[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]([Cl:11])[c:7]1[C:8](=[O:9])[Cl:10]>>[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]([Cl:11])[c:7]1[C:8](=[O:9])[N:20]([CH2:19][CH2:18][O:17][Si:16]([C:12]([CH3:13])([CH3:14])[CH3:15])([CH3:39])[CH3:40])[c:21]1[c:22]([F:38])[cH:23][c:24]([CH:27]2[CH2:28][CH2:29][CH:30]([CH2:33][C:34](=[O:35])[O:36][CH3:37])[CH2:31][CH2:32]2)[cH:25][cH:26]1Participants
4
Sources & evidence
- ORD record
- ord-03441946c6924005a60897c6cae43570
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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