Dichloromethane → N-[2-[[1-(4-aminocyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide

HRID 837869Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH:16]([NH:18][C:19]([CH2:20][NH:21][C:22]([c:23]3[cH:24][c:25]([C:29]([F:30])([F:31])[F:32])[cH:26][cH:27][cH:28]3)=[O:33])=[O:34])[CH2:17]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:35].[Cl:43][CH2:44][Cl:45].[F:36][C:37]([F:38])([F:39])[C:40]([OH:41])=[O:42]>>[NH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH:16]([NH:18][C:19]([CH2:20][NH:21][C:22]([c:23]3[cH:24][c:25]([C:29]([F:30])([F:31])[F:32])[cH:26][cH:27][cH:28]3)=[O:33])=[O:34])[CH2:17]2)[CH2:12][CH2:13]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 59541119{4-{3-[2-(3-Trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester

Product 1

HCID 59541166N-[2-[[1-(4-aminocyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide

Sources & evidence

ORD record: ord-59187141b6cf4d5b8c89405c5c5322d2
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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