Sodium ion → Methyl 2-(4-fluorophenoxy)-5-(trifluoromethyl)nicotinate

HRID 837947Notes

Reaction equation

HRID 837947 reaction equation
[Cl:31][CH2:32][Cl:33].[Cu:29][I:30].[F:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[c:8]([C:9](=[O:10])[O:11][CH3:12])[cH:13][c:14]([I:17])[cH:15][n:16]2)[cH:18][cH:19]1.[F:20][C:21]([C:22]([O-:23])=[O:24])([F:25])[F:26].[Na+:27].[OH2:28]>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[c:8]([C:9](=[O:10])[O:11][CH3:12])[cH:13][c:14]([C:21]([F:20])([F:25])[F:26])[cH:15][n:16]2)[cH:18][cH:19]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 6344DichloromethaneHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 84468TrifluoroacetateHCID 57572293Methyl 2-(4-fluorophenoxy)-5-iodonicotinate

Product 1

HCID 57572267Methyl 2-(4-fluorophenoxy)-5-(trifluoromethyl)nicotinate

Sources & evidence

ORD record
ord-0b21f3ee386c4fdaaca8cfa34a3ecd77
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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