反应详情

(4-Nitrophenoxy)-acetic acid-2-hydroxyethyl ester 23 (1 g, 4.15 mmol) was dissolved in ethyl acetate in a pressure vessel. Palladium on carbon (5%, 0.5 g) was added and the mixture stirred under an atmosphere of hydrogen (0.5 kg) for one hour. Catalyst was removed by filtration, the ethyl acetate distilled off and hexane added. The solid product was filtered and dried to give pure 28 (0.2 g 22.8%) as a brown powder with an m.p. between 104-106.3° C.

1. customCatalyst was removed by filtration
2. distillationthe ethyl acetate distilled off
3. additionhexane added
4. filtrationThe solid product was filtered
5. customdried
6. customto give pure 28 (0.2 g 22.8%) as a brown powder with an m.p. between 104-106.3° C.