反应详情

Dry HCl gas was passed through a mixture of 2-(4-nitrophenoxy)-propionic acid 29 (45 g, 213 mol) and ethylene glycol (135 ml) for 1½ hours. During HCl gas bubbling the temperature rose to 60° C. The crude reaction mass was poured onto cold water (600 ml). Crude 30 was extracted into chloroform, dried over Na2SO4, distilled and purified by column chromatography on silica gel using hexane as eluant to give pure 30 (28 g, 56.8%) as a syrup.

1. customDuring HCl gas bubbling the temperature
2. customrose to 60° C
3. customThe crude reaction mass
4. extractionCrude 30 was extracted into chloroform
5. dry with materialdried over Na2SO4
6. distillationdistilled
7. custompurified by column chromatography on silica gel