Hydrochloric Acid → 1-{5-[4-(2,2-Difluoro-cyclopropylmethyl)-piperazin-1-yl]-pyridin-2-yl}-1,2,3,4-tetrahydroquinoxaline

HRID 838030Notes

Reaction equation

HRID 838030 reaction equation
[ClH:32].[F:1][C:2]1([F:31])[CH:3]([CH2:5][N:6]2[CH2:7][CH2:8][N:9]([c:12]3[cH:13][cH:14][c:15]([N:18]4[CH2:19][CH2:20][N:21]([C:28]([OH:29])=[O:30])[c:22]5[cH:23][cH:24][cH:25][cH:26][c:27]54)[n:16][cH:17]3)[CH2:10][CH2:11]2)[CH2:4]1.[O:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1>>[F:1][C:2]1([F:31])[CH:3]([CH2:5][N:6]2[CH2:7][CH2:8][N:9]([c:12]3[cH:13][cH:14][c:15]([N:18]4[CH2:19][CH2:20][NH:21][c:22]5[cH:23][cH:24][cH:25][cH:26][c:27]54)[n:16][cH:17]3)[CH2:10][CH2:11]2)[CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 687373104-{5-[4-(2,2-difluoro-cyclopropylmethyl)-piperazin-1-yl]-pyridin-2-yl}-3,4-dihydro-2H-quinoxaline-1-carboxylic acid

Product 1

HCID 669259181-{5-[4-(2,2-Difluoro-cyclopropylmethyl)-piperazin-1-yl]-pyridin-2-yl}-1,2,3,4-tetrahydroquinoxaline

Sources & evidence

ORD record
ord-727d547a8a1f4f3aba8c9beaf8609e54
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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