Dichloromethane → N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-5-(methyl(piperidin-4-yl)amino)-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

HRID 838644Notes

Reaction equation

[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[c:15]([CH3:48])[c:16]([N:33]([CH:34]3[CH2:35][CH2:36][N:37]([C:40]([O:41][C:42]([CH3:43])([CH3:44])[CH3:45])=[O:46])[CH2:38][CH2:39]3)[CH3:47])[cH:17][c:18](-[c:20]3[cH:21][cH:22][c:23]([CH2:26][N:27]4[CH2:28][CH2:29][O:30][CH2:31][CH2:32]4)[cH:24][cH:25]3)[cH:19]2)[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1.[Cl:56][CH2:57][Cl:58].[F:49][C:50]([F:51])([F:52])[C:53]([OH:54])=[O:55]>>[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[c:15]([CH3:48])[c:16]([N:33]([CH:34]3[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]3)[CH3:47])[cH:17][c:18](-[c:20]3[cH:21][cH:22][c:23]([CH2:26][N:27]4[CH2:28][CH2:29][O:30][CH2:31][CH2:32]4)[cH:24][cH:25]3)[cH:19]2)[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 70872920Tert-butyl 4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)(methyl)amino)piperidine-1-carboxylate

Product 1

HCID 70872465N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-5-(methyl(piperidin-4-yl)amino)-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

Sources & evidence

ORD record: ord-a2bee8a3b044412e924151939e79269a
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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