Sodium ion → ethyl 3-methoxy-4-[[4-propan-2-yl-4-[4-[4-(trifluoromethyl)-2-pyridinyl]piperazine-1-carbonyl]cyclopent-2-en-1-yl]amino]piperidine-1-carboxylate

HRID 838771Notes

Reaction equation

HRID 838771 reaction equation
[C:52]([O:53][BH-:54]([O:55][C:56](=[O:57])[CH3:58])[O:59][C:60](=[O:61])[CH3:62])(=[O:63])[CH3:64].[CH2:15]([Cl:16])[Cl:17].[CH3:1][O:2][CH:3]1[CH2:4][N:5]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH2:6][CH2:7][C:8]1=[O:9].[CH3:45][CH2:46][N:47]([CH2:48][CH3:49])[CH2:50][CH3:51].[CH:18]([CH3:19])([CH3:20])[C:21]1([C:27](=[O:28])[N:29]2[CH2:30][CH2:31][N:32]([c:35]3[n:36][cH:37][cH:38][c:39]([C:41]([F:42])([F:43])[F:44])[cH:40]3)[CH2:33][CH2:34]2)[CH:22]=[CH:23][CH:24]([NH2:26])[CH2:25]1.[Na+:65]>>[CH3:1][O:2][CH:3]1[CH2:4][N:5]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH2:6][CH2:7][CH:8]1[NH:26][CH:24]1[CH:23]=[CH:22][C:21]([CH:18]([CH3:19])[CH3:20])([C:27](=[O:28])[N:29]2[CH2:30][CH2:31][N:32]([c:35]3[n:36][cH:37][cH:38][c:39]([C:41]([F:42])([F:43])[F:44])[cH:40]3)[CH2:33][CH2:34]2)[CH2:25]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6344DichloromethaneHCID 8471TriethylamineHCID 2724451Ethyl 3-methoxy-4-oxopiperidine-1-carboxylateHCID 2724942TriacetoxyborohydrideHCID 69149575(4-Amino-1-propan-2-ylcyclopent-2-en-1-yl)-[4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methanone

Product 1

HCID 178473347ethyl 3-methoxy-4-[[4-propan-2-yl-4-[4-[4-(trifluoromethyl)-2-pyridinyl]piperazine-1-carbonyl]cyclopent-2-en-1-yl]amino]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-c30e687de93e4547b00f2879b2b86a94
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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