Beta-Alanine → HCID 70621101, compound

HRID 838791Notes

Reaction equation

HRID 838791 reaction equation
[N-:1]=[C:2]=[O:3].[NH2:4][CH:5]([C:10]([OH:12])=O)[CH2:6][CH2:7][S:8][CH3:9].N1C=CC=CC=1.N[CH2:20][CH2:21][C:22]([OH:24])=[O:23]>CO>[C:22]([CH2:21][CH2:20][N:1]1[C:10](=[O:12])[CH:5]([CH2:6][CH2:7][S:8][CH3:9])[NH:4][C:2]1=[O:3])([OH:24])=[O:23]

Participants

6

Reactant 4

HCID 239Beta-AlanineHCID 876(+-)-MethionineHCID 1049PyridineHCID 105034Isocyanate

Product 1

HCID 70621101HCID 70621101, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

189 g (1 mole) of the isocyanate derivative of the methyl ester of dl-methionine are poured slowly into a pyridine solution of β-alanine (89 g, 1 mole). The reaction takes place spontaneously, accompanied by the elimination of methanol. The reaction medium is then concentrated to dryness under reduced pressure. The residue is purified by recrystallisation from dichlorethane.

Workup

  1. concentrationThe reaction medium is then concentrated to dryness under reduced pressure
  2. customThe residue is purified by recrystallisation from dichlorethane

Sources & evidence

ORD record
ord-ee2b4fc91f4344e6b74031011d37c05d
Source dataset
uspto-grants-1978_06
Patent number
US04093444

Reaction notes

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