反应详情

温度

60 °C

To a solution of 3-fluoro-4-methylbenzoic acid (13.23 g, 85.85 mmol) in EtOH (200 mL) at 0° C. was added SOCl2 (3 mL) dropwise. The reaction mixture was heated at 60° C. overnight, then cooled to room temperature, concentrated under reduced pressure and diluted with DCM. The organic layer was washed with 1N NaOH (100 mL×2), dried (MgSO4) and concentrated to give ethyl 3-fluoro-4-methylbenzoate (15.02 g, 96%).

1. temperaturecooled to room temperature
2. concentrationconcentrated under reduced pressure
3. additiondiluted with DCM
4. washThe organic layer was washed with 1N NaOH (100 mL×2)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated