関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-Fluoro-p-toluic acid | HCID 67687 | — |
| 生成物 | Benzoic acid, 3-fluoro-4-methyl-, ethyl ester | HCID 13489923 | 96% |
反応手順
To a solution of 3-fluoro-4-methylbenzoic acid (13.23 g, 85.85 mmol) in EtOH (200 mL) at 0° C. was added SOCl2 (3 mL) dropwise. The reaction mixture was heated at 60° C. overnight, then cooled to room temperature, concentrated under reduced pressure and diluted with DCM. The organic layer was washed with 1N NaOH (100 mL×2), dried (MgSO4) and concentrated to give ethyl 3-fluoro-4-methylbenzoate (15.02 g, 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846739B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-aa98154a31db4f65b8fcf189a6479cdc |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
