反应详情

To a stirred solution of methyl-lithium in ether (60ml, 2M solution) at room temperature was added over 0.5 hours 7-hydroxy-4-(1-naphthyl)coumarin (7.5g, 0.025 moles). The reaction mixture was refluxed for 2 hours, allowed to cool and decomposed by the addition of dilute hydrochloric acid. The organic layer was separated, the aqueous layer extracted with ether (2×) and the combined organic extracts washed with water and dried. Removal of solvent gave the required title chromene as an orange oil (7.22g, 95%).

1. temperatureThe reaction mixture was refluxed for 2 hours
2. temperatureto cool
3. customThe organic layer was separated
4. extractionthe aqueous layer extracted with ether (2×)
5. washthe combined organic extracts washed with water
6. customdried
7. customRemoval of solvent