HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2-(4-Methyl-1-piperazinyl)-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Product | 2-(4-Methyl-1-piperazinyl)-1H-benzimidazole | HCID 2773180 | — |
Reaction Steps
2-chlorobenzimidazole (5.0 g) and piperazine (8.0 g) were dissolved in 10 ml isopropyl alcohol and reflexed 6.5 hours. The solution was concentrated in vacuo. The residue treated with sodium carbonate and then extracted with chloroform to yield 5.55 g product. mp. 222°-224° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04093726 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-29f4366dcedf42f39e9c7ea964b4ae5d |
| Source note | uspto-grants-1978_06 |