Isopropanol → 2-(4-Methyl-1-piperazinyl)-1H-benzimidazole

HRID 838972Notes

Reaction equation

HRID 838972 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH:17](O)(C)C>>[CH3:17][N:11]1[CH2:16][CH2:15][N:14]([C:2]2[NH:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=2)[CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 4837PiperazineHCID 785722-Chlorobenzimidazole

Product 1

HCID 27731802-(4-Methyl-1-piperazinyl)-1H-benzimidazole

Procedure

2-chlorobenzimidazole (5.0 g) and piperazine (8.0 g) were dissolved in 10 ml isopropyl alcohol and reflexed 6.5 hours. The solution was concentrated in vacuo. The residue treated with sodium carbonate and then extracted with chloroform to yield 5.55 g product. mp. 222°-224° C.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. additionThe residue treated with sodium carbonate
  3. extractionextracted with chloroform

Sources & evidence

ORD record
ord-29f4366dcedf42f39e9c7ea964b4ae5d
Source dataset
uspto-grants-1978_06
Patent number
US04093726

Reaction notes

Loading…