Epibromohydrin → 7-(2-Oxiranylmethoxy)-1(2H)-phthalazinone

HRID 838977Notes

Reaction equation

HRID 838977 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[N:7][NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[CH2:13]([CH:15]1[O:17][CH2:16]1)Br>>[O:17]1[CH2:16][CH:15]1[CH2:13][O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[N:7][NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18430EpibromohydrinHCID 135729098HCID 135729098, compound

Product 1

HCID 203254967-(2-Oxiranylmethoxy)-1(2H)-phthalazinone

Procedure

7-Hydroxy-1(2H)-phthalazinone was reacted with epibromohydrin in a similar manner to that described in Example 1(iii) to give 7-(2,3-epoxypropoxy)-1(2H)-phthalazinone, which after recrystallisation from ethyl acetate had m.p. 164°-166°.

Sources & evidence

ORD record
ord-f952617a72b745ca9318e09568c0031a
Source dataset
uspto-grants-1978_06
Patent number
US04093725

Reaction notes

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