Sodium Pyrosulfite → HCID 135729097, compound

HRID 838983Notes

Reaction equation

HRID 838983 reaction equation
[Cl:1][O-].[Na+].[OH:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[N:10][NH:11][C:12]2=[O:15])=[CH:7][CH:6]=1.S(S([O-])=O)([O-])(=O)=O.[Na+].[Na+]>[OH-].[Na+]>[Cl:1][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:5]=1[OH:4])[C:12](=[O:15])[NH:11][N:10]=[CH:9]2

Participants

5

Reactant 3

HCID 656671Sodium PyrosulfiteHCID 23665760Sodium HypochloriteHCID 135729098HCID 135729098, compound

Product 1

HCID 135729097HCID 135729097, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Sodium hypochlorite solution (10% w/v chlorine, 175 ml) was added to a stirred solution of 7-hydroxy-1(2H)-phthalazinone (10 g, 0.062 mol) in aqueous sodium hydroxide (2N, 140 ml), and the stirring was continued for two hours. An excess of sodium metabisulphite was added to the reaction mixture, and the precipitate was recrystallised from ethanol to give 6-chloro-7-hydroxy-1(2H)-phthalazinone, m.p. > 340° (decomp), which was purified via the acetyl derivative m.p. 190°-192° as described in Example 4(i).

Workup

  1. customthe precipitate was recrystallised from ethanol

Sources & evidence

ORD record
ord-5141a7989f1641fe8f88e37cb8ba4d59
Source dataset
uspto-grants-1978_06
Patent number
US04093725

Reaction notes

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