反应详情

To a solution of 3.4 g of [5-[(2,2-dichlorocyclopropylmethyl)thio]-1H-benzimidazol-2-yl]carbamic acid, methyl ester in 50 ml of CHCl3 and 50 ml of HOAc at -20° C there is added 2.1 g m-chloroperbenzoic acid in 20 ml of CHCl3. The mixture is allowed to reach room temperature and then is stirred for 4 hours. CHCl3 is removed in vacuo and the solution is neutralized with NaOH. The resulting oil solid is filtered and crystallized from glyme-ethyl ether to give the title compound.

1. customto reach room temperature
2. customCHCl3 is removed in vacuo
3. filtrationThe resulting oil solid is filtered
4. customcrystallized from glyme-ethyl ether