反应详情

Dry hydrogen chloride gas was passed into a solution of N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl] thiourea (73.2 g) in methanol (600 ml) and the mixture was refluxed for 5 hours. Concentration and re-evaporation with isopropyl alcohol afforded a crystalline solid which was recrystallised from isopropyl alcohol-ether to give N,S-dimethyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]isothiourea dihydrochloride (96.2 g) m.p. 191°-192° (isopropyl alcohol-ether).

1. temperaturethe mixture was refluxed for 5 hours
2. concentrationConcentration and re-evaporation with isopropyl alcohol
3. customafforded a crystalline solid which
4. customwas recrystallised from isopropyl alcohol-ether