HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → HCID 54019979, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1,1,1,3,3,3-Hexafluoro-2-(4-(methylamino)phenyl)propan-2-OL | HCID 805015 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 54019979 | HCID 54019979 | 99.5% |
Reaction Steps
To a cold (10°) stirred mixture of 137 g (0.50 mole) 4-(hexafluoro-2-hydroxy-2-propyl)-N-methyl aniline in 500 ml Et2O and 168 g (2.0 mole) NaHCO3 in 500 ml H2O add dropwise 500 g (0.6 mole) 12% phosgene in benzene over 1 hour. Add 500 ml Et2O, separate the organic phase, dry, concentrate and wash the residue with hexane to give 167 g white solid; m.p. 152°-154°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04093742 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-893850d504c44bf498e70d621c0f5f1e |
| Source note | uspto-grants-1978_06 |