反应详情

To a cold (10°) stirred mixture of 137 g (0.50 mole) 4-(hexafluoro-2-hydroxy-2-propyl)-N-methyl aniline in 500 ml Et2O and 168 g (2.0 mole) NaHCO3 in 500 ml H2O add dropwise 500 g (0.6 mole) 12% phosgene in benzene over 1 hour. Add 500 ml Et2O, separate the organic phase, dry, concentrate and wash the residue with hexane to give 167 g white solid; m.p. 152°-154°.

1. customseparate the organic phase
2. customdry
3. concentrationconcentrate
4. washwash the residue with hexane