Ammonia → HCID 54046793, compound

HRID 839069Notes

Reaction equation

HRID 839069 reaction equation
[NH3:1].[CH3:2][N:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([OH:22])([C:18]([F:21])([F:20])[F:19])[C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1)[C:4](Cl)=[O:5]>CCOCC>[CH3:2][N:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([OH:22])([C:18]([F:21])([F:20])[F:19])[C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1)[C:4]([NH2:1])=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54019979HCID 54019979, compound

Product 1

HCID 54046793HCID 54046793, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Saturate with NH3 a solution of 6.7 g (20 mmole) N-methyl-N-[4-(hexafluoro-2-hydroxy-2-propyl)phenyl]carbamyl chloride in 200 ml Et2O. After 24 hours, wash the Et2O with water, then 1N HCl. Dry, concentrate and recrystallize the solid from ether-hexane to give 5.0 g white solid; m.p. 181°-184°.

Workup

  1. washwash the Et2O with water
  2. customDry
  3. concentrationconcentrate
  4. customrecrystallize the solid from ether-hexane

Sources & evidence

ORD record
ord-0b268b092fe2432987414e65e58af06b
Source dataset
uspto-grants-1978_06
Patent number
US04093742

Reaction notes

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