Sodium Iodide → HCID 54377100, compound

HRID 839169Notes

Reaction equation

HRID 839169 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[O:16][CH3:17])O.[I-:18].[Na+]>CC(=O)CC>[CH3:17][O:16][C:10]1[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=1[CH:7]=[CH:6][CH2:5][CH2:4][CH2:3][CH2:2][I:18]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 20389995HCID 20389995, compound

Product 1

HCID 54377100HCID 54377100, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 74 g. of 5-bromopentyl 2-methoxy-4-chlorophenyl carbinol, 50 g. of sodium iodide and 500 ml. of 2-butanone was heated under reflux for 2.5 days. The reaction mixture was concentrated, water added and the mixture extracted with ether. The ether extracts were dried over anhydrous magnesium sulfate and concentrated to give 84 g. of oil used directly in the next reaction without further purification.

Workup

  1. additionA mixture of 74 g
  2. temperatureunder reflux for 2.5 days
  3. concentrationThe reaction mixture was concentrated
  4. additionwater added
  5. extractionthe mixture extracted with ether
  6. dry with materialThe ether extracts were dried over anhydrous magnesium sulfate
  7. concentrationconcentrated
  8. customto give 84 g
  9. customof oil used directly in the next reaction without further purification

Sources & evidence

ORD record
ord-fe6ebde043d04a999286714038911b63
Source dataset
uspto-grants-1978_06
Patent number
US04093736

Reaction notes

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