Hydrochloric Acid → HCID 12682411, compound

HRID 839182Notes

Reaction equation

HRID 839182 reaction equation
[CH3:1][CH:2]([P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])[CH2:3][CH:4](OCC)[O:5]CC.Cl>O.CC(C)=O>[CH3:1][CH:2]([P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])[CH2:3][CH:4]=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 12682408HCID 12682408, compound

Product 1

HCID 12682411HCID 12682411, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Conditions

Temperature
62 °C

Procedure

A solution of 400 grams (1.42 moles) of diethyl 1-methyl-3,3-diethoxypropylphosphonate in 1 liter of water and 4 liters of acetone containing 30 ml of concentrated hydrochloric acid was stirred and refluxed under nitrogen at 62° C for 1.5 hours. Low boiling materials were removed at 80° C/16 mm to give the diethyl 1-methyl-3-oxopropylphosphonate in a 296 grams (quantitative) yield as a pale yellow liquid. The structure was confirmed by NMR.

Workup

  1. customwere removed at 80° C/16 mm

Sources & evidence

ORD record
ord-e68aaef3766345da97ca1e3f72abd0c2
Source dataset
uspto-grants-1978_06
Patent number
US04093809

Reaction notes

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