Ammonia → HCID 178526568, compound

HRID 839194Notes

Reaction equation

HRID 839194 reaction equation
N.[CH2:2]1[O:23][CH:5]([C:6]2[C:7]([C:15]3[O:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=3)=[N:8][N:9](C(OC)=O)[CH:10]=2)[O:4][CH2:3]1.Cl>O>[CH2:3]1[O:4][CH:5]([C:6]2[C:7]([C:15]3[O:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=3)=[N:8][NH:9][CH:10]=2)[O:23][CH2:2]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 203260461-Methoxycarbonyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehyde-ethyleneacetal

Product 1

HCID 178526568HCID 178526568, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Add 29 ml of concentrated ammonia solution (in 200 ml. of dimethylformamide and 50 ml of water) dropwise at room temperature to a suspension of 51 g of 1-methoxycarbonyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehyde-ethyleneacetal. Stir for 20 minutes until dissolution takes place. Acidify with 2N hydrochloric acid to a pH of from 5 to 6 to throw down a precipitate. Add 50 ml of water dropwise, stir for a further 15 minutes at room temperture, draw off the precipitate and wash with water to obtain 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehyde-ethyleneacetal [m.p. 166° to 167° C]with a yield of 79%.

Workup

  1. stirringstir for a further 15 minutes at room temperture
  2. washwash with water

Sources & evidence

ORD record
ord-ccc229eb4ee24bd59a7f85e7aec88193
Source dataset
uspto-grants-1978_06
Patent number
US04093812

Reaction notes

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