反应详情

Add 29 ml of concentrated ammonia solution (in 200 ml. of dimethylformamide and 50 ml of water) dropwise at room temperature to a suspension of 51 g of 1-methoxycarbonyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehyde-ethyleneacetal. Stir for 20 minutes until dissolution takes place. Acidify with 2N hydrochloric acid to a pH of from 5 to 6 to throw down a precipitate. Add 50 ml of water dropwise, stir for a further 15 minutes at room temperture, draw off the precipitate and wash with water to obtain 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehyde-ethyleneacetal [m.p. 166° to 167° C]with a yield of 79%.

1. stirringstir for a further 15 minutes at room temperture
2. washwash with water