HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(5-Nitrofuran-2-yl)-1-(propan-2-yl)-1H-pyrazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 54174528 | HCID 54174528 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 3-(5-Nitrofuran-2-yl)-1-(propan-2-yl)-1H-pyrazole-4-carbonitrile | HCID 20326239 | 99% |
Reaction Steps
Stir an admixture of 3.4 g of finely pulverized 1-isopropyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehydeoxime in 15 ml of 1,2-dichloroethane with 1.8 g of thionyl chloride for 80 minutes at 55° C. Evaporate the resulting solution to dryness in vacuo and then evaporate to dryness twice more after mixing with 1,2-dichloroethane to obtain a 99% yield of 1-isopropyl-3-(5-nitro-2-furyl)pyrazole-4-carbonitrile [m.p. 181° to 182° C (from ethanol)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04093812 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-971fce8fe12045ab826c3779d49a4bde |
| Source note | uspto-grants-1978_06 |