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HRID839220

反应详情

EQUATION

反应方程式

HRID 839220 的结构方程式

REACTANTS

反应物

2
结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：CC(C)n1cc(C=NO)c(-c2ccc([N+](=O)[O-])o2)n1
HCID54174528

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)n1cc(C#N)c(-c2ccc([N+](=O)[O-])o2)n1
HCID20326239

3-(5-Nitrofuran-2-yl)-1-(propan-2-yl)-1H-pyrazole-4-carbonitrile

C11H10N4O3

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

Stir an admixture of 3.4 g of finely pulverized 1-isopropyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehydeoxime in 15 ml of 1,2-dichloroethane with 1.8 g of thionyl chloride for 80 minutes at 55° C. Evaporate the resulting solution to dryness in vacuo and then evaporate to dryness twice more after mixing with 1,2-dichloroethane to obtain a 99% yield of 1-isopropyl-3-(5-nitro-2-furyl)pyrazole-4-carbonitrile [m.p. 181° to 182° C (from ethanol)].

WORKUP

后处理

  1. customEvaporate the resulting solution to dryness in vacuo
  2. customevaporate to dryness twice more
  3. additionafter mixing with 1,2-dichloroethane