HRID839225

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1118

Sulfuric acid

H2O4S

反应SMILES：Cn1cc(C#N)c(-c2ccc([N+](=O)[O-])o2)n1

HCID20326043

1-Methyl-3-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbonitrile

C9H6N4O3

PRODUCTS

产物

反应SMILES：Cn1cc(C(N)=O)c(-c2ccc([N+](=O)[O-])o2)n1

HCID20326060

1-Methyl-3-(5-nitrofuran-2-yl)-1H-pyrazole-4-carboxamide

C9H8N4O4

收率 97%

PROCEDURE

实验过程

While cooling and stirring 80 ml of concentrated sulfuric acid at room temperature, add 40 g of 1-methyl-3-(5-nitro-2-furyl)pyrazole-4-carbonitrile thereto. Then stir the resulting mixture for 21 hours at room temperature. Pour thus-obtained solution onto ice for a 97% yield of 1-methyl-3-(5-nitro-2-furyl)pyrazole-4-carboxamide [m.p. 251° to 252.5° C].

WORKUP

后处理

temperatureWhile cooling
additionPour