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HRID839228

反应详情

EQUATION

反应方程式

HRID 839228 的结构方程式

REACTANTS

反应物

3
结构：O=P(Cl)(Cl)Cl
HCID24813

Phosphoric trichloride

Cl3OP

结构：O=C(Cl)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20325933

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbonyl chloride

C14H8ClN3O4

结构：O=C(O)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20325964

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carboxylic acid

C14H9N3O5

PRODUCTS

生成物

1
结构：NC(=O)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20326123

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carboxamide

C14H10N4O4

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(Cl)Cl
溶剂HCID6365

1,1-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

Heat 1 g of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxylic acid together with 0.56 g of phosphorus oxychloride and 10 ml of dichloroethane for 2 hours at 80° C. Add 10 ml of a 25% aqueous solution dropwise at 0° C to the thus-obtained solution of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxylic chloride. Allow the resulting mixture to stand overnight and then vacuum distil it to remove the organic solvent therefrom. Vacuum filter to separate formed precipitate and recrystallize the filter residue from dimethylformamide/methanol to obtain 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxamide [m.p. 236° to 238° C].

WORKUP

后处理

  1. customvacuum distil it
  2. customto remove the organic solvent
  3. filtrationVacuum filter
  4. customto separate
  5. customformed precipitate
  6. customrecrystallize the filter residue from dimethylformamide/methanol