Nitric Acid → 1-Methyl-5-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbonitrile

HRID 839233Notes

Reaction equation

HRID 839233 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]([CH3:11])[N:9]=[CH:8][C:7]=1[C:12]#[N:13].C(OC(=O)C)(=O)C.[N+:21]([O-])([OH:23])=[O:22]>>[CH3:11][N:10]1[C:6]([C:2]2[O:1][C:5]([N+:21]([O-:23])=[O:22])=[CH:4][CH:3]=2)=[C:7]([C:12]#[N:13])[CH:8]=[N:9]1

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 7918Acetic AnhydrideHCID 20326245HCID 20326245, compound

Product 1

HCID 203260631-Methyl-5-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbonitrile

Procedure

Following the procedure of Example 21, react 1.3 g of 5-(2-furyl)-1-methylpyrazole-4-carbonitrile [German Offenlegungsschrift (DOS) 1,809,386] with 11.5 ml of acetic anhydride and 3 ml of 65% nitric acid to obtain 1-methyl-5-(5-nitro-2-furyl)pyrazole-4-carbonitrile [m.p. 149.5° to 151.5° C].

Sources & evidence

ORD record
ord-2cca975e37f5410bbadde656edbdbd1d
Source dataset
uspto-grants-1978_06
Patent number
US04093812

Reaction notes

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