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HRID839238

反应详情

EQUATION

反应方程式

HRID 839238 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：O=NOS(=O)(=O)O
HCID82157

Nitrosylsulfuric acid

HNO5S

结构：NC(=O)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20326123

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carboxamide

C14H10N4O4

PRODUCTS

生成物

1
结构：O=C(O)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20325964

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carboxylic acid

C14H9N3O5

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=P(O)(O)O
溶剂HCID1004

Phosphoric acid

H3O4P

PROCEDURE

实验过程

Add 36 g of 98% nitrosylsulfuric acid (under cooling with ice) dropwise to a suspension of 50 g 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxamide in 830 ml of 89% orthophosphoric acid, whereupon the temperature rises from 0° C to 35° C. Stir the resulting reaction mixture for 18 hours at room temperature and pour the produced solution onto 5 kg of ice and water. Separate the formed precipitate and wash it with water until it is no longer acid to obtain a 98% yield of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxylic acid [m.p. 264° to 265.5° C (with decomposition) from dioxane].

WORKUP

后处理

  1. customrises from 0° C to 35° C
  2. customthe resulting reaction mixture for 18 hours at room temperature
  3. customSeparate the formed precipitate
  4. washwash it with water until it