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HRID839239

反应详情

EQUATION

反应方程式

HRID 839239 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：NC(=O)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20326123

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carboxamide

C14H10N4O4

PRODUCTS

生成物

1
结构：O=C(Cl)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20325933

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbonyl chloride

C14H8ClN3O4

收率 89%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)(Cl)Cl
溶剂HCID5943

Carbon tetrachloride

CCl4

PROCEDURE

实验过程

Heat 40 g of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxamide together with 290 ml of thionyl chloride and 1 ml of dimethylformamide for 16 hours at boiling point. Cool the resulting solution, draw off the formed precipitate and wash it with thionyl chloride and with carbon tetrachloride to obtain an 89% yield of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxylic acid chloride [m.p. 208° to 210° C (from dioxane)].

WORKUP

后处理

  1. temperatureCool the resulting solution
  2. washwash it with thionyl chloride