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HRID839242

反应详情

EQUATION

反应方程式

HRID 839242 的结构方程式

REACTANTS

反应物

2
结构：C1CCNC1
HCID31268

Pyrrolidine

C4H9N

结构：O=C(Cl)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20325933

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbonyl chloride

C14H8ClN3O4

PRODUCTS

生成物

1
结构：O=C(c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1)N1CCCC1
HCID20325993

[3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl](pyrrolidin-1-yl)methanone

C18H16N4O4

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

PROCEDURE

实验过程

Add 1.06 ml. of pyrrolidine in 2 ml of dioxane dropwise to 1.0 g of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxylic acid chloride in 43 ml of dioxane at 35° C under stirring. Stir the resulting solution for an hour at room temperature and then concentrate it. Wash the resulting precipitate with water to obtain a 99% yield of 1-[3-(5-nitro-2-furyl)-1-phenyl-4-pyrazolylcarbonyl]pyrrolidine [m.p. 236.5° to 237.5° C].

WORKUP

后处理

  1. additionAdd 1.06 ml
  2. concentrationconcentrate it
  3. washWash the resulting precipitate with water