Morpholine → 4-(2-Nitro-4-(trifluoromethyl)phenyl)morpholine

HRID 839251Notes

Reaction equation

HRID 839251 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.C(N(CC)CC)C>C(COC)OC>[N+:12]([C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)([O-:14])=[O:13]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 84624-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotolueneHCID 8471Triethylamine

Product 1

HCID 27757934-(2-Nitro-4-(trifluoromethyl)phenyl)morpholine

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

4-(2-Nitro-4-trifluoromethylphenyl)morpholine was prepared by reaction of 4-chloro-3-nitrobenzotrifluoride with equimolar amounts of morpholine and triethylamine in monoglyme. The resultant product melts at 37°-39° C.

Sources & evidence

ORD record
ord-5752faba9137438d912229619e5e0e33
Source dataset
uspto-grants-1978_06
Patent number
US04094662

Reaction notes

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