HCID 746766, compound → 3-[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]propanoic acid

HRID 839426Notes

Reaction equation

HRID 839426 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH:13]=[CH:14][C:15]([OH:17])=[O:16])=[CH:11][N:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:9]=2)=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:11][N:10]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 746766HCID 746766, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 136616563-[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]propanoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the corresponding acrylic acid derivative of Example 5 (1.0 g.) and palladium-on-charcoal (0.25 g. of 10%) in ethanol (50 ml.) was shaken in an atmosphere of hydrogen until uptake of hydrogen had ceased. Removal of the catalyst by filtration, evaporation of the filtrate and recrystallisation of the residue gave 0.25 g. of the title compound.

Workup

  1. customRemoval of the catalyst
  2. filtrationby filtration, evaporation of the filtrate and recrystallisation of the residue
  3. customgave 0.25 g

Sources & evidence

ORD record
ord-aa84a3ea217642dab5fcbd2c7bd2c1f7
Source dataset
uspto-grants-1978_06
Patent number
US04095025

Reaction notes

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