1-Propanesulfonyl chloride → HCID 86735763, compound

HRID 839482Notes

Reaction equation

HRID 839482 reaction equation
[CH2:1]([S:4](Cl)(=[O:6])=[O:5])[CH2:2][CH3:3].[NH2:8][NH:9][C:10]([NH:12][NH2:13])=[O:11].C(=O)(O)[O-].[Na+]>C(O)C>[CH2:1]([S:4]([NH:8][NH:9][C:10]([NH:12][NH:13][S:4]([CH2:1][CH2:2][CH3:3])(=[O:6])=[O:5])=[O:11])(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 662791-Propanesulfonyl chlorideHCID 73948CarbohydrazideHCID 516892Sodium Bicarbonate

Product 1

HCID 86735763HCID 86735763, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Into a 1-liter reaction flask was charged 29.5 g (0.2 mole) n-propane sulfonyl chloride, 200 ml ethanol, 9 g (0.1 mole) carbohydrazide and 16.8 g (0.2 mole) sodium bicarbonate. The mix was stirred and heated gradually to 80° C over a one hour period and was then allowed to reflux for four hours. The separated sodium chloride was filtered off (hot). The filtrate was cooled whereupon the crystalline product separated (17 g) m.p. 191°-194° C.

Workup

  1. customInto a 1-liter reaction flask
  2. temperatureto reflux for four hours
  3. filtrationThe separated sodium chloride was filtered off (hot)
  4. temperatureThe filtrate was cooled whereupon the crystalline product
  5. customseparated (17 g) m.p. 191°-194° C.

Sources & evidence

ORD record
ord-ae9a94ba05f5464a8376dea34d0c9dc9
Source dataset
uspto-grants-1978_06
Patent number
US04096100

Reaction notes

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